We investigate the patterns and mechanisms of genomic variation in disease

Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule.

Our study illuminates long-term cancer evolution under the sea and reveals tolerance of extreme instability in neoplastic genomes.

Our contribution
to the Pan-Cancer initiative is out in Nature Genetics

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

The Pan-Cancer marker paper describing the genomic features in >3,500 whole-genomes just published in Nature.

We find 140 LINE-1 loci in the human genome, which may contribute to cancer mutations and behave as volcanoes.

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.

These data underscore the importance of characterising liver cancer genomes for patterns of HBV integration.

Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe.